14 yrs old adolescent female, a known child with renal stone disease detected at 9 months of age on alkali therapy. She underwent ESWL 3 yrs ago when she developed acute kidney injury secondary to stone obstruction. She recovered from AKI. Her renal functions were stable with the creatinine of 1.2 to 1.5 till november 2013. Now she presented with the creatinine of 3.9. There is no stone obstruction, no evidence of dehydration and sepsis(reversible causes of AKI). Since beginning we have done crystalluria evaluation many times for her which was essentially normal. Parents want to go for RRT in the form of transplant. We have sent genetic analysis for oxalosis. Can we do the genetic study for all the patient with RSD difficult to manage/going for renal failure. What is the current guidelines? If we prove the oxalosis then no point in doing renal transplant alone, We should go for combined liver and kidney transplant