Home Forums Other Specialities Cardiothoracic Medicine & Surgery STATIN DISCONTINUATION- CONSEQUENCES

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      Anonymous
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      Negative statin-related news stories decrease
      statin persistence and increase myocardial
      infarction and cardiovascular mortality:
      a nationwide prospective cohort study
      EUROPEAN HEART JOURNAL- 6 November 2015.

      Aim
      We tested the hypothesis that statin-related news stories, cardiovascular disease, diabetes, statin dose, calendar year,
      and socio-demographic status are associated with early statin discontinuation. We also examined frequency and consequences
      of early statin discontinuation.
      Methods
      and results
      From the entire Danish population, we studied 674 900 individuals aged 40 or older who were initiated on statin therapy
      in 1995–2010, and followed them until 31 December 2011.

      Individuals on statins increased from ,1% in 1995 to
      11% in 2010, while early statin discontinuation increased from 6% in 1995 to 18% in 2010. The odds ratios for early
      statin discontinuation vs. continued use were 1.09 (95% confidence interval, 1.06–1.12) for negative statin-related
      news stories, 1.04 (1.02–1.07) per increasing calendar year, 1.04 (1.02–1.06) per increasing defined daily dose of statin,
      1.05 (1.03–1.06) for male sex, 1.13 (1.11–1.15) for living in cities, 1.67 (1.63–1.71) for other ethnicity than Danish, 0.92
      (0.90–0.94) for positive statin-related news stories, 0.73 (0.72–0.74) for baseline cardiovascular disease, and 0.91
      (0.90–0.93) for baseline diabetes.

      During follow-up, the hazard ratios for individuals with vs. without early statin discontinuation
      were 1.26 (1.21–1.30) for myocardial infarction and 1.18 (1.14–1.23) for death from cardiovascular
      disease.

      Conclusion
      Early statin discontinuation increased with negative statin-related news stories, calendar year, statin dose, male sex, living
      in cities, and with other ethnicity than Danish, while the opposite was true for positive statin-related news stories
      and for baseline cardiovascular disease and diabetes.

      Early statin discontinuation was also associated with increased risk
      of myocardial infarction and death from cardiovascular disease.

      G Mohan.

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