Drug safety advice
Dabigatran (Pradaxa): contraindicated in patients with prosthetic heart valve(s) requiring anti-coagulant treatment, because of the risk of thrombosis and haemorrhage
Dabigatran (Pradaxa) is now contraindicated in patients with prosthetic heart valves requiring anti-coagulant treatment related to their valve surgery. This is regardless of the length of time elapsed since valve replacement took place.

Aqueous cream: may cause skin irritation, particularly in children with eczema, possibly due to sodium lauryl sulfate content
Aqueous cream may cause local skin reactions, such as stinging, burning, itching, and redness, when it is used as a leave-on emollient, particularly in children with atopic eczema. The reactions, which are not generally serious, often occur within 20 minutes of application but can occur later.

G.Mohan