Home › Forums › Other Specialities › Therapeutics › Dexamathasone or Methyl prednisiolone for Covid 19
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August 8, 2022 at 12:50 am #2660AnonymousInactive
International Journal of Infectious Diseases
Published:July 08, 2022DOI:https://doi.org/10.1016/j.ijid.2022.07.019
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Dexamethasone was more effective than methylprednisolone in the treatment of COVID-19.
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Hospitalization time was shorter in the dexamethasone group.
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The duration of oxygen therapy was shorter in the dexamethasone group.
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Hypokalemia and hyperglycemia were higher in the methylprednisolone group.
Abstract
Objective
In this study, we aimed to compare the effects of intravenous dexamethasone and methylprednisolone on the treatment of inpatients with COVID-19.
Methods
In this randomized clinical trial, 143 patients under 80 years of age with moderate to severe COVID-19 were enrolled and randomly assigned to two groups: dexamethasone (8 mg/day) and methylprednisolone (60 mg/day in two divided doses). The primary outcome was the length of hospital stay. The secondary outcomes included: duration of oxygen therapy, absolute leukocyte and lymphocyte count, hypokalemia, hyperglycemia, intensive care unit admission, and mortality in the two groups for 28 days. Data were analyzed by SPSS version 26 using t-test, chi-square, and analysis of variance.
Results
The duration of hospitalization was significantly (P <0.001) shorter in the dexamethasone group than in the methylprednisolone group (8 [95% confidence interval [CI]:6-10] and 11 [95% CI: 7-14], respectively). In addition, the duration of oxygen therapy in the dexamethasone group (7 [95% CI: 5-9]) was significantly (P <0.001) shorter than in the methylprednisolone group (10 [95% CI: 5.5-14]). The mortality rate was 17.1% (95% CI: 8.1-26.1) in the dexamethasone group and 12.3% (95% CI: 4.6-20.0) in the methylprednisolone group, which was not statistically significant (P = 0.46).
Conclusion
Results showed better effectiveness of 8 mg/day dexamethasone compared with 60 mg/day methylprednisolone based on the shorter hospital stay, which can be considered in the therapeutic protocol of COVID-19.G Mohan.
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