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    PATIENTS WITH CELIAC DISEASE: A 2-YEAR FOLLOW-UP Of Anaemia

    The American Journal of Gastroenterology: June 17, 2022 – Volume – Issue – 10.14309/

    OBJECTIVES: Anemia and micronutrient deficiencies are common in newly-diagnosed patients with celiac disease (CeD). We aim to determine the prevalence and etiology of anemia in a cohort of patients with CeD in the U.S. and examine the effect of a gluten-free diet (GFD) on the laboratory parameters related to anemia in CeD.

    METHODS: We analyzed a prospectively-collected cohort of adults with biopsy-proven CeD followed in a specialized CeD center between January 2000 and June 2016. We used the level of hemoglobin (Hb) and micronutrients suggested by the World Health Organization (WHO) to establish the diagnosis of anemia or deficiencies. Information on demographics and laboratory parameters related to anemia and micronutrients were recorded at the time of diagnosis and on a GFD. A celiac expert nutritionist or gastroenterologist evaluated all patients.

    RESULTS: In 572 patients with laboratory evaluation before starting a GFD, about 25% presented with anemia at the time of diagnosis of CeD. Iron-deficiency was present in 50.8% of the cohort and in 78.8% of the anemic patients. Within the anemic population, 84.4% of female as compared to 58.3% of male patients (p=0.02) showed iron deficiency. Folate deficiency (23.2%), vitamin B12 deficiency (11%), and anemia of chronic diseases (7.8%) were also part of both genders’ anemia etiology. Of the initially anemic patients, 81% and 89% normalized their Hb level within one year and two years of beginning a GFD, respectively. All patients received appropriate supplementation when needed.

    CONCLUSIONS: About twenty-five percent of individuals have anemia at CeD diagnosis. The anemia etiology included iron deficiency, vitamin deficiencies, and anemia of chronic diseases. The majority of patients will normalize their Hb levels and the anemia laboratory parameters one year after starting a strict GFD.

    G Mohan

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