Continuing Medical Education Am J Gastroenterol 2013; 108:1558–1563; doi: 10.1038/ajg.2013.147; published online 28 May 2013
Acute Gastroenteritis and the Risk of Functional Dyspepsia: A Systematic Review and Meta-Analysis
Brian L Pike PhD, MPH1, Chad K Porter PhD1, Tia J Sorrell MPH1 and Mark S Riddle MD, DrPH1
1Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA
Correspondence: Brian L. Pike, PhD, MPH, Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, Maryland 20910-7500, USA. E-mail: brian.pike@med.navy.mil
Abstract
OBJECTIVES: The objective of this systematic review and meta-analysis was to estimate the risk of developing functional dyspepsia (FD) following acute infectious gastroenteritis (IGE).METHODS:Eligible studies were identified through PubMed and EMBASE searches. Data and quality indicators were extracted by two authors from nine studies examining the risk of FD following IGE in 5,755 exposed individuals
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RESULTS: Estimates of FD risk following IGE based on a random effects model yielded a pooled odds ratio (OR) of 2.18 (95% confidence interval (CI): 1.70–2.81). Subanalyses revealed differences in the odds of FD following self-reported IGE (OR: 2.83, 95% CI: 2.10–3.81) compared with documented IGE medical encounters (OR: 1.81, 95% CI: 1.26–2.58), and a decreasing FD risk with time from IGE (?12 months: OR: 4.76, 95% CI: 2.47–9.20 and >12 months: OR: 1.97, 95% CI: 1.51–2.56).
CONCLUSIONS: Taken together, these data suggest that the risk of developing FD is significantly increased following IGE.
